Recruiting

Testing a shorter, stronger treatment plan for drug-sensitive tuberculosis

Plain-English translation of NCT05401071 on ClinicalTrials.gov ↗ · Source last updated December 2023 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing rifapentine, a tuberculosis medication, to see if it can treat drug-sensitive tuberculosis in a shorter period than traditional therapy. The study will compare two different doses of this medication combined with other standard TB drugs. The goal is to find a faster, easier treatment plan that helps people stick with their medicine and get cured.

Many tuberculosis patients don't finish their treatment because current regimens are long and complex, which leads to incomplete cures, drug resistance, and continued spread of disease. This trial aims to develop a shorter, better-tolerated treatment plan that could help more people complete their therapy and prevent the emergence of hard-to-treat TB.

Do you qualify?

You likely qualify if…

you are between 18 and 60 years old
you weigh between 40 and 80 kilograms (88–176 pounds)
you have been diagnosed with drug-sensitive pulmonary tuberculosis
you are willing to use effective contraception during treatment if you are a non-menopausal woman
you can provide informed consent or, if under 18, have parental consent

You likely don't qualify if…

you have tuberculosis that has spread outside the lungs
you have very extensive lung damage (more than 50% of lung tissue affected or cavities larger than 4 centimeters)
your TB bacteria are already resistant to any of the study medications
you have significant liver or kidney problems, very low blood cell counts, or a heart condition called prolonged QT syndrome
you are pregnant, breastfeeding, or living with AIDS

What participation looks like

If you join this trial, you will take a combination of TB medications for 17 to 26 weeks total. The first 8 weeks is an intensive phase where you take four medications together, followed by a 9-week continuation phase with three medications. Depending on how well you respond, your treatment may be extended by up to another 9 weeks. You will have regular check-ups and tests to monitor how well the medication is working and to check for any side effects.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Testing a shorter, stronger treatment plan for drug-sensitive tuberculosis

What is this trial?

Do you qualify?

What participation looks like

Trial locations