Plain-English translation of NCT05401630 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is looking at why some postmenopausal women have chest pain and heart problems even though their major heart arteries are not blocked. The researchers want to understand how stress and anxiety affect the tiny blood vessels in the heart and whether this stress response leads to serious heart events. By studying three groups of women—those with small vessel heart disease, those with traditional blockages, and healthy controls—the team hopes to develop better ways to diagnose and treat these patients.
Many women are told their hearts are fine after angiography shows no major blockages, yet they continue to have chest pain and serious heart problems. This trial exists because doctors need to understand why stress makes symptoms worse in these women and how to better treat them, especially since current treatment options are limited.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would be placed into one of three groups based on your heart condition. You would visit the research center to undergo cardiac imaging scans (including a special scan that shows how your heart's nervous system responds to stress) and mental stress testing, where researchers monitor your heart's response to challenging tasks designed to increase stress. The study is currently recruiting participants, and the researchers will explain all procedures and answer your questions before you decide to join.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
United States