Plain-English translation of NCT05402163 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two ways of delivering deep brain stimulation (DBS) for Parkinson's disease: standard continuous stimulation that stays at a fixed level, and adaptive stimulation that automatically adjusts based on real-time signals from your brain. The study tests whether the adaptive approach works just as well for movement problems but works better for speech, walking, and balance issues that sometimes worsen with standard stimulation.
Many people with Parkinson's find that standard brain stimulation doesn't help—or even worsens—their walking, speech, and balance problems. This new treatment uses the brain's electrical signals to adjust stimulation moment-to-moment, which may better address these difficult symptoms that currently have few good treatment options.
You will have your current stimulation device replaced with a new adaptive device. The trial is divided into two phases where you will receive both types of stimulation (standard and adaptive) in random order, and neither you nor your doctors will know which you're using at any given time—this helps ensure fair comparison. Throughout the study, your symptoms and brain signals will be monitored to see how each stimulation approach affects your walking, speech, balance, and overall quality of life.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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