Plain-English translation of NCT05404230 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether high-dose fish oil (a supplement containing omega-3 fatty acids called EPA and DHA) can prevent or reduce nerve damage in your hands and feet after you receive oxaliplatin chemotherapy for colorectal cancer. You would take either fish oil capsules or corn oil capsules (a placebo, or comparison treatment) for 8 months. Researchers will check whether the medication helps protect your nerves and also track your thinking, mood, and nutritional health.
Oxaliplatin is an effective chemotherapy drug, but it commonly causes nerve damage that can cause tingling, numbness, and pain in the extremities—sometimes for a long time after treatment ends. This study is exploring whether this treatment might prevent or reduce that side effect, which would improve quality of life for colorectal cancer survivors.
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You would take 4 capsules by mouth each day for 8 months—either fish oil or corn oil (assigned randomly). You would visit the study team for check-ins to assess whether you are developing nerve damage, and they would measure your thinking, mood, and nutrition. At some visits, the researchers would take small skin samples (biopsies) and blood samples to study the biology of nerve damage. The entire study lasts about 8 months after you finish your chemotherapy.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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