Plain-English translation of NCT05409794 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Researchers want to understand whether people naturally have lithium in their blood, and whether natural lithium levels might be protective against suicidal thoughts and behaviors. This study will compare lithium levels in people with depression who have had suicidal thoughts or attempts in the past year with those who haven't. By measuring natural lithium in the blood, scientists hope to better understand the biology behind suicide risk and develop better ways to help people.
Lithium is a medication that has long been known to help reduce suicide risk in certain mental health conditions, but doctors don't fully understand why. This research aims to discover whether people naturally produce protective levels of this substance in their bodies, which could lead to new prevention strategies for people at highest risk.
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Your participation takes just one day. A doctor will meet with you to review your medical history and current symptoms, and then a small will be taken to measure natural lithium levels. The researchers will ask you questions about any suicidal thoughts or behaviors you may have experienced, your mood changes, and your impulses. That's it—no ongoing visits or medications to take as part of this study.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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