Testing a stool sample test to detect colon cancer in Lynch syndrome patients

This research study is evaluating a test called multitarget stool DNA (mt-sDNA) 2.0 to see if it can reliably detect colon cancer or precancerous polyps in people who have Lynch syndrome, a hereditary genetic condition. Researchers want to understand how accurate this stool test is compared to colonoscopy, the standard screening procedure. The study will also build a collection of blood and stool samples from Lynch syndrome patients to help scientists better understand early-onset colon cancer.

Lynch syndrome puts people at very high risk for colon cancer, often at younger ages than the general population. Current screening relies on colonoscopy, which is invasive and requires special preparation. This trial exists to see whether a simple stool test could be an effective screening tool to catch cancer or precancerous growths earlier in people with this genetic condition.