Spinal cord stimulation for nerve pain after chemotherapy

Plain-English translation of NCT05411523 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial is studying a medical device called a 10-kHz spinal cord stimulator—a small implant that sends mild electrical pulses to help reduce nerve pain. The study is looking at whether this device can help people who developed painful nerve damage from chemotherapy drugs, especially in their legs and feet. Researchers want to measure how much pain relief people get and how the treatment affects their sleep, mood, and overall quality of life.

Nerve pain after chemotherapy can be severe and difficult to treat with medications alone, leaving many patients still struggling with pain and reduced quality of life. This trial exists to see whether this stimulation device is an effective option for people whose pain hasn't improved with standard pain medications.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with chemotherapy-induced nerve pain that started more than six months after completing chemotherapy
your lower extremity pain is moderate to severe (at least 5 out of 10 on a pain scale) at enrollment
you have tried at least two different nerve pain medications without adequate relief
you had a successful trial of the spinal cord stimulator device that reduced your pain by at least 75 percent
your cancer is in remission or treated, and your neurological condition is stable

You likely don't qualify if…

you have a life expectancy of less than one year
you have untreated cancer that is actively spreading
you have active or untreated substance abuse, or a severe untreated psychiatric condition
you have a bleeding disorder or serious heart or lung disease that would make surgery unsafe
you have another painful condition unrelated to your chemotherapy nerve pain that is not being addressed in this study

What participation looks like

If you are already receiving spinal cord stimulation therapy, you would complete surveys about your pain, nerve function, sleep, and overall quality of life at four timepoints: when you start (baseline) and then at 3, 6, and 12 months afterward. Each survey takes about 30 minutes. This is an observational study, meaning researchers are tracking how the device you already have works for you—you are not being assigned to a new treatment.

AI-generated summary from trial data · Jun 1, 2026 · Not medical advice

Trial locations(1 site)

United States

Mayo Clinic in Rochester, Rochester, Minnesota