Plain-English translation of NCT05411614 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a newer surgical approach called convergent hybrid ablation against the standard catheter ablation procedure for treating persistent atrial fibrillation (an irregular heartbeat) in people who also have heart failure. The hybrid approach combines a minimally-invasive surgical step with a catheter procedure, while the standard approach uses only the catheter method. Researchers want to see which approach works better and is safer for patients whose hearts are weakened by both conditions.
Persistent atrial fibrillation combined with heart failure is challenging to treat, and many patients don't respond well to standard catheter ablation alone. This trial is exploring whether adding a surgical component might give patients better results and improve their heart function.
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If assigned to the hybrid approach, you would undergo two procedures: first, a minimally-invasive surgical procedure on the outer surface of your heart, and then a catheter procedure inside your heart. If assigned to standard care, you would receive only the catheter procedure. After treatment, you'll have follow-up visits to monitor your heart rhythm and symptoms over 24 months, with special attention to how well the treatment works starting 3 months after your procedure.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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