Testing common pain relievers to prevent cancer in Lynch syndrome

This trial is testing whether naproxen or aspirin — two common over-the-counter pain relievers — might help prevent cancer in people with Lynch syndrome. Researchers will look at how these medications affect immune cells in the colon and other tissues, and whether they can reduce polyp growth. The goal is to understand if this simple, affordable approach could lower cancer risk in people with this genetic condition.

People with Lynch syndrome have a much higher risk of developing colorectal cancer and other cancers because of a genetic mutation. There is no proven way to prevent these cancers yet, so researchers want to test whether this medication might work by boosting the immune system's ability to stop cancer from developing.