Plain-English translation of NCT05413122 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing four evidence-based approaches to help people living with HIV quit smoking in South Africa. You may receive intensive counseling, peer support, combination nicotine replacement therapy (nicotine patches and gum), (a prescription medication that reduces cravings), or combinations of these treatments. The researchers want to understand which approaches work best and how much they cost to deliver.
People living with HIV smoke at much higher rates than the general population, which puts them at greater risk of serious health problems. This trial exists to figure out the most effective and affordable way to help this group quit smoking as part of their regular HIV care.
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You will be randomly assigned to one of 16 different combinations of treatments over 12 weeks. Depending on your assignment, you may attend in-person counseling sessions at the clinic (lasting about 45 minutes), receive phone calls and text messages from counselors, and meet with a peer counselor at locations of your choice. Some participants will take nicotine replacement products or . The study involves regular visits and check-ins to track your progress and support your efforts to quit smoking.
AI-generated summary from trial data · Jun 29, 2026 · Not medical advice
South Africa