Plain-English translation of NCT05414045 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether doctors can transplant testicular tissue that was frozen when you were a boy — before cancer or blood disorder treatment — back into your body as an adult to help you produce sperm again. The tissue was preserved years ago specifically for this purpose. Researchers will perform the transplant and monitor whether it helps restore your fertility so you can have biological children.
Cancer and blood disorder treatments can damage or destroy a man's ability to produce sperm, affecting his fertility. This trial exists because freezing testicular tissue in boys before treatment has been possible for over 20 years, but doctors have never actually transplanted this tissue back to see if it works to restore fertility in adult men.
You likely qualify if…
You likely don't qualify if…
When you contact the center requesting the transplant, doctors will first run blood tests and analyze your semen to confirm you don't have usable sperm. If confirmed, you will undergo surgery to have your thawed testicular tissue transplanted back into your testicles. After the procedure, you will have follow-up visits and testing to see if your body begins producing sperm again, which typically takes several months to a year or more. If successful, you may then pursue natural conception or standard fertility treatments to have children.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
Belgium
Sponsor
Universitair Ziekenhuis Brussel
Collaborators
Vrije Universiteit Brussel
Enrollment target
~5 participants
Started
November 2024
Primary completion
July 2030
Age range
18 Years – 50 Years
Sex
Male only
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Veerle Vloeberghs, MD
CRG UZ Brussel
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.