Plain-English translation of NCT05416684 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
After certain types of brain surgery, patients need a piece of material implanted to cover and protect the skull. This trial compares two options: one made of a plastic-like material called PEEK and one made of titanium mesh. The study will track patients for one year to see which material has fewer problems, heals better, and helps people recover their brain function more successfully.
Doctors need to know which skull implant material is safest and most effective. Some implants can become infected or fail, requiring removal and another surgery. This study will provide clear evidence to help doctors choose the best option for future patients.
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You will undergo skull reconstruction surgery using either the PEEK or titanium implant (your doctor will help decide which is appropriate). After surgery, you will have follow-up appointments at 3, 6, and 12 months to check for complications, assess how well your wound is healing, and evaluate your neurological function and recovery. The study team will monitor for any problems like infection or implant failure during this one-year period.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
China
Sponsor
RenJi Hospital
Enrollment target
~358 participants
Started
November 2024
Primary completion
September 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in November 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Zhiyi Zhou
RenJi Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.