Plain-English translation of NCT05417555 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called Low Intensity Focused Ultrasound (LIFUP) — a painless, non-invasive procedure that uses sound waves to stimulate a part of your brain involved in memory and learning. Researchers want to see whether this treatment can help improve memory and thinking in people diagnosed with mild cognitive impairment or mild Alzheimer's disease. The study will measure how the treatment affects your brain activity and memory performance over five weeks.
Early memory loss and mild cognitive decline can progress to more serious dementia, and current treatment options are limited. Researchers believe gently stimulating specific brain regions involved in memory might help improve thinking and learning, offering a new non-invasive approach to slowing or reducing memory problems.
Over about five weeks, you'll attend one online intake session (1–2 hours), three in-person visits at UCLA (5 hours, 3 hours, and 3 hours), and three follow-up sessions online (about 2 hours each). During in-person visits, you'll complete memory and learning tests, have blood drawn, and receive ultrasound stimulation inside an MRI scanner while researchers watch your brain activity in real time. You'll be randomly assigned to receive either one, two, or three doses of the treatment, or no treatment at all (placebo); if the treatment works and you were in the placebo group, you'll be offered a free treatment session afterward.
AI-generated summary from trial data · Sep 2, 2026 · Not medical advice
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