Testing a new cancer drug alone and with other treatments

Plain-English translation of NCT05417594 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new cancer medication called to see if it is safe and effective for people with advanced cancers. The study will test the medication by itself, and also in combination with other existing cancer treatments. Researchers want to find the right dose and understand how well this treatment works for different types of cancer.

Some advanced cancers have specific genetic mutations that make cancer cells vulnerable to a new type of treatment. This medication is designed to target those mutations and stop cancer growth, but doctors need to test whether it is safe and truly helps patients before it can be used more widely.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced or relapsed cancer (breast, ovarian, pancreatic, prostate, or brain cancer, depending on the study arm)
your cancer has specific genetic mutations in genes like BRCA1, BRCA2, PALB2, RAD51C, or RAD51D
your cancer has gotten worse or returned despite previous treatment
you have adequate organ and bone marrow function as shown by blood tests
you are able to follow fasting instructions and dietary requirements during the study

You likely don't qualify if…

you are pregnant or planning to become pregnant during the study
you have untreated brain tumors that need immediate surgery or radiation (depending on the study arm)
your cancer has not progressed and remains stable on your current treatment
you have severe organ damage or very low blood cell counts
you are unable to commit to the study visits and follow-up schedule

What participation looks like

If you join this study, you will receive the new medication either as a single treatment or combined with other cancer drugs, depending on which study group you are assigned to. You will visit the research clinic regularly for blood tests, imaging scans, and checkups to monitor how you are responding and to watch for any side effects. The study involves multiple cycles of treatment, and researchers will carefully track your health throughout to determine if the medication is working safely.

AI-generated summary from trial data · Aug 23, 2026 · Not medical advice

Trial locations(32 sites)

United States

Research Site, La Jolla, California

Research Site, Los Angeles, California

Research Site, San Francisco, California

Research Site, Chicago, Illinois

Research Site, Boston, Massachusetts