Plain-English translation of NCT05420935 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is investigating why some people have severe, life-threatening allergic reactions to medications used during surgery — particularly muscle relaxants (curare) and antibiotics. Researchers want to understand the immune system's role in these reactions by collecting blood and bone marrow samples from people who have experienced them. By studying these samples in the laboratory, they hope to better predict and prevent these dangerous allergic reactions in the future.
Severe allergic reactions during surgery can be fatal, occurring in about 1 in 10,000 patients. Currently, doctors diagnose these reactions based on one type of immune antibody (IgE), but about 10-20% of patients don't show signs of this antibody, meaning we don't fully understand what causes their reactions. This study aims to fill that gap by identifying other immune markers that might explain why some people react so dangerously to these medications.
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You will visit the research center for a single study visit. All participants will provide a small blood sample (5 ml) for a basophil activation test. Depending on which group you're in, you may also provide a larger blood donation (250 ml) and/or a bone marrow sample (approximately 2 ml, taken from the breastbone under local anesthesia). The researchers will then analyze these samples in the laboratory to study your immune system's response to the medication that caused your reaction.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
France