Exercise and CoQ10 supplement for kidney disease muscle weakness

This trial is testing whether CoQ10, a natural compound that helps cells produce energy, combined with exercise can help people with end-stage kidney disease rebuild muscle strength and reduce frailty. Many dialysis patients experience unusual weakness and muscle loss at younger ages than the general population, and researchers believe that improving how cells work—particularly the energy-producing structures called mitochondria—may help reverse this. The study will compare CoQ10 alone, exercise alone, both together, or neither over 12 weeks.

About 73% of people starting dialysis experience frailty and muscle weakness, which makes everyday activities harder and increases health risks. Current standard care doesn't always address the root cause: cells may not be producing energy efficiently, making muscles weak even when muscle size seems adequate. This trial explores whether boosting cellular energy production and building strength through exercise can prevent or reverse this debilitating condition.