Plain-English translation of NCT05423444 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our PTSD research guide โThis study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This research study is testing whether a well-established therapy called Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) changes how the brain works in teenagers with PTSD from abuse or violence. Researchers will use brain scans to see what happens in different parts of the brain as teenagers go through the three phases of treatment. This helps doctors understand exactly how and why this treatment works, so they can develop better or more personalized approaches for youth who don't improve with current methods.
About 1 in 5 teenagers with PTSD don't improve enough with today's standard treatments, and doctors don't fully understand how the brain changes during therapy. By tracking brain activity throughout the treatment phases, this study aims to unlock the biological mechanisms that make therapy work โ knowledge that could lead to better or personalized treatments for struggling youth.
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You will be randomly assigned to receive either Trauma-Focused Cognitive Behavioral Therapy delivered by study clinicians or treatment as usual in your community. Either way, you'll attend weekly sessions for 18 weeks. You'll also have brain scans (MRI) at the start of treatment, after each of the three therapy phases, and at the end โ this lets researchers watch how your brain changes as you learn new skills and process your trauma safely.
AI-generated summary from trial data ยท Jun 2, 2026 ยท Not medical advice
United States