Plain-English translation of NCT05424692 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a new approach to choosing chemotherapy can help colorectal cancer patients do better after surgery. Instead of picking chemotherapy based on standard guidelines alone, researchers will test your tumor in the laboratory to see which chemotherapy drugs it responds to best. Half of participants will receive chemotherapy chosen this personalized way, while the other half will receive chemotherapy chosen using standard clinical experience.
Currently, doctors choose chemotherapy for colorectal cancer based on general guidelines that work for many patients, but not necessarily the best choice for each individual. This trial is testing whether using laboratory sensitivity testing to match drugs to each patient's specific tumor could improve survival and reduce unnecessary side effects.
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If you join this study, your tumor sample from surgery will be used to perform a specialized laboratory test that shows which chemotherapy drugs work best against your cancer. You will be randomly assigned to either receive chemotherapy selected based on these test results, or chemotherapy chosen using standard clinical guidelines. You will receive the chemotherapy treatment as planned, and the study will follow you for three years to track whether your cancer returns and how well you are doing. Researchers will also analyze your tumor's genetic information to help predict your long-term outcome.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
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