Plain-English translation of NCT05426408 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is a pilot study investigating why some people have heart attacks even though their coronary arteries (the blood vessels that supply the heart) look normal on angiography—a standard imaging test. Researchers will use advanced heart imaging called cardiac magnetic resonance (CMR) scans, sometimes with an additional medication called adenosine, to find hidden problems in the tiny blood vessels of the heart that may explain these heart attacks.
Currently, doctors struggle to diagnose and explain heart attacks in patients whose main coronary arteries appear healthy on standard tests. By identifying the prevalence and characteristics of microvascular dysfunction (problems in the heart's smallest blood vessels) using this imaging approach, the study aims to improve how doctors recognize and treat this condition.
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As a participant, you would undergo cardiac magnetic resonance (CMR) imaging scans—a type of advanced heart imaging that uses magnetic fields and radio waves to create detailed pictures of your heart. Some of these scans may include adenosine, a medication that temporarily increases blood flow to the heart to help doctors see how your small blood vessels function. You would serve as your own control, meaning your scans will be compared to see how your heart responds under different conditions.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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