Plain-English translation of NCT05427435 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new catheter — a thin tube inserted through blood vessels — that uses ethanol (a sterilizing agent) to treat a part of your heart called the vein of Marshall. In people with persistent atrial fibrillation (a condition where the heart's upper chambers beat irregularly), this medication can help destroy tissue that triggers abnormal heartbeats. The study wants to see if this new specialized catheter makes the treatment easier and more effective than current methods.
Standard ablation procedures for persistent atrial fibrillation only work about half the time. The vein of Marshall is known to be a source of irregular heartbeats, but doctors haven't had the right tools to safely target it. This trial exists to test whether a dedicated catheter can finally make it simple and safe to treat this area, potentially improving outcomes for patients.
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You will undergo a catheter ablation procedure at the hospital, during which doctors will use the specialized catheter to identify and treat the vein of Marshall in your heart using ethanol. The procedure is similar to standard heart ablation but includes this additional step to target this specific area. You will receive appropriate anesthesia and monitoring during the procedure, and follow-up care will be arranged to monitor your heart rhythm recovery.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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