Plain-English translation of NCT05432856 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Breast cancer survivors face an increased risk of heart disease, not just from cancer treatments themselves, but also from metabolic changes like weight gain and insulin resistance that happen during and after treatment. This study is testing whether two lifestyle approaches—time-restricted eating (eating within a shorter window each day) combined with strategies to reduce sitting time, versus standard nutrition and exercise guidelines—can help protect your heart and metabolism during chemotherapy. Researchers will use special imaging and health monitoring to see which approach works best.
While cancer treatments have improved survival, many breast cancer survivors now die from heart disease rather than cancer itself. Recent research shows that the way fat accumulates in the body during cancer treatment—even in people with normal weight—is a major hidden risk factor for heart problems. This trial aims to find practical lifestyle changes that can prevent these metabolic and heart complications from happening in the first place.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two groups. One group will receive personalized coaching on time-restricted eating, nutritional counseling, strategies to reduce sitting time, and a Fitbit monitor to track activity—all introduced gradually over 24 weeks. The other group will receive a single group class on nutrition during cancer, printed guidelines, and a Fitbit monitor. Both groups will have MRI scans and health assessments at the beginning and end of the study to measure changes in fat distribution and heart health. The study lasts about 6 months while you receive your chemotherapy.
AI-generated summary from trial data · Sep 4, 2026 · Not medical advice
Canada