Recruiting

Testing a new cancer treatment in advanced tumor patients

Plain-English translation of NCT05434234 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated August 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

This is one of the first times this treatment has been tested in people.

What is this trial?

This is a first-in-human study testing a new medication called in patients with advanced solid tumors. Researchers will first find the right dose by gradually increasing it in small groups of patients, then test that dose in larger groups to understand how safe the medication is and how well it works.

Many patients with advanced cancers run out of treatment options when standard therapies stop working or cause too many side effects. This trial aims to see if this new medication could offer hope to those patients.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with an advanced solid tumor that has not responded to standard treatment or for which no standard treatment exists
you are in generally good health with a life expectancy of at least 3 months
you have at least one tumor that can be measured on imaging scans
you are willing and able to follow all study visits and procedures
you agree to use effective birth control during the study and for several months after

You likely don't qualify if…

you have received chemotherapy or other cancer treatments within the past 2–3 weeks
you have had radiation therapy to your abdomen within the past 4 weeks
you have had major surgery within the past 4 weeks or are planning surgery during the study
you have received a bone marrow or stem cell transplant recently
you are currently taking high-dose steroids or have received a live vaccine within the past 4 weeks

What participation looks like

The study has two phases: first, small groups of patients receive gradually increasing doses to find the safest and most effective dose; then, larger groups of patients receive that dose to confirm safety and measure how well the medication works. You will have regular visits for blood tests, imaging scans, and check-ins with your doctor to monitor how you are responding and watch for any side effects.

AI-generated summary from trial data · Aug 21, 2026 · Not medical advice

Trial locations(45 sites)

United States

002, Fair Oaks, California

001, La Jolla, California

003, Lone Tree, Colorado

004, Washington D.C., District of Columbia

005, Boston, Massachusetts