Plain-English translation of NCT05437705 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing a treatment called repetitive Transcranial Magnetic Stimulation (rTMS), which uses magnetic pulses to gently stimulate specific areas of your brain. The researchers are using MRI brain scans to customize the treatment for each person individually, then testing whether the personalized version works better than a non-optimized version for reducing rumination, depression, and anxiety.
Current brain stimulation treatments use the same settings for everyone, but brains are different. This study aims to find out whether personalizing the treatment to match each person's unique brain activity could make rTMS more effective at relieving symptoms of depression and anxiety.
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You would come in for about 11 visits over roughly 10 weeks. The first visit includes screening and a brief demonstration of the magnetic stimulation (about 3–4 hours total). Then you'll have MRI brain scans and receive magnetic stimulation sessions in small groups of 3 visits each, with tasks and questionnaires in between to see how you're feeling. Each session lasts 1–2.5 hours depending on what's being done. You'll also be asked to avoid alcohol before scans, not use recreational drugs during the study, and not start any new medications.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
United States