Plain-English translation of NCT05439135 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing washed microbiota transplantation (WMT)—a treatment that introduces healthy gut bacteria—for people who developed malnutrition after having stomach surgery that changed the way their digestive system works. Researchers want to find the best way to deliver this treatment: through a tube placed in the middle part of the small intestine, or through a tube placed in the colon. The goal is to see if this medication can help restore your nutrition and improve how you feel.
When surgeons rearrange the stomach and intestines to treat cancer or other conditions, patients often struggle with severe malnutrition because food doesn't move through the digestive system the same way anymore. This trial exists to test whether introducing healthy gut bacteria can fix this problem and to figure out which delivery method works best.
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You will start with nutrition support through a feeding tube when you enroll. Then you'll be randomly assigned to receive three microbiota transplantations through either a tube in your mid-gut or a tube in your colon. After treatment, you'll eat a regular diet while continuing home nutrition support for 8 weeks. During this time, you'll provide blood, urine, and stool samples at the start and at 8 weeks to measure how well your nutrition has improved.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
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