Plain-English translation of NCT05442216 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether three medications used together — , , and — can help treat acute myeloid leukemia (a serious blood cancer) in people whose cancer developed after they received earlier treatment with hypomethylating agents. The study will enroll about 53 people to see if this three-drug combination works better than standard approaches.
Some patients with this type of blood cancer don't respond well to standard treatments, or their cancer returns after initial therapy. Researchers believe combining these three medications in a specific sequence might help more patients achieve remission and live longer.
You likely qualify if…
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You would receive treatment in 28-day cycles. Each cycle involves receiving as an IV infusion for 3 days, followed by (as an injection or infusion) and (a pill) for several days. Doctors will check your bone marrow with a biopsy around day 24 of your first cycle to see if the treatment is working. Depending on your response, you may continue with additional cycles of treatment, with biopsies performed every few cycles to monitor your progress.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
United States