Plain-English translation of NCT05444907 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why some Parkinson's patients develop manic episodes (periods of extremely elevated mood) after receiving deep brain stimulation surgery. By comparing patients who experienced this side effect with those who didn't, the study aims to identify which surgical placements and electrical settings might trigger these mood changes, and whether certain personality or health factors make someone more likely to be affected.
While deep brain stimulation helps many Parkinson's patients improve their movement and quality of life, some patients experience severe mood changes as a side effect. When this happens, doctors often have to turn off or adjust the device, causing patients to lose the benefits they gained. This study exists to predict who might be at risk before it happens, so doctors can prevent it or catch it earlier.
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You will meet with researchers who will ask detailed questions about your medical history, Parkinson's symptoms, and any mood changes you've noticed since your surgery. They will review your surgical records to see exactly where your electrode was placed and what electrical settings were used. Some participants may have brain imaging or additional assessments. The study compares two groups: patients who developed mood changes and patients who didn't, so researchers can find the differences between them.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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