Plain-English translation of NCT05445180 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how cannabis affects thinking, memory, and brain structure — especially in people with psychosis. This study will ask some participants to stop using cannabis for 28 days while others continue as usual, and compare how their brains and memory change using MRI scans. The goal is to learn whether the brain can recover after stopping cannabis use.
Many people with psychosis use cannabis, and we know it affects how the brain works and how people think and remember. However, doctors don't yet understand exactly what happens to the brain when someone stops using cannabis, or whether the brain can heal. This research could help develop better treatments for people struggling with cannabis use.
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You will visit the research clinic at baseline and again after 28 days. At each visit, you'll have an MRI brain scan while completing a memory task, and provide urine samples twice weekly to verify abstinence if you're in the abstinence group. If assigned to stop cannabis use, you'll receive rewards (contingency management) for staying abstinent during the 28 days. The entire study takes about four weeks.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
Canada