Plain-English translation of NCT05445544 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is an observational study following 10,000 pregnant women in China to understand the role of microbes (bacteria and other organisms) in the body and how they might help doctors detect preeclampsia — a dangerous condition that can develop during pregnancy — earlier than current methods allow. Researchers will collect samples from your body at different stages of pregnancy and after delivery to study the composition of these microbes and other chemical markers.
Preeclampsia is a serious pregnancy complication that can threaten both mother and baby if not caught early. This study aims to discover new biological markers and patterns that could help doctors identify which women are at high risk for preeclampsia before symptoms develop, potentially allowing for earlier monitoring and treatment.
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You would visit the hospital four times during pregnancy (around weeks 11-14, 22-28, 32-34, and at delivery) and five times after birth (at 6 weeks, 6 months, 1 year, and 2 years) to provide samples. At each visit, researchers will collect urine, blood, saliva, vaginal swabs, and stool samples using simple, non-invasive procedures. If you have a caesarean delivery, additional samples like placenta and amniotic fluid may be collected. The study lasts about two years from when you enroll.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
China
Sponsor
Zhujiang Hospital
Collaborators
Nanfang Hospital, Southern Medical University, Tianjin Central Hospital of Gynecology Obstetrics
Enrollment target
~10,000 participants
Started
October 2022
Primary completion
December 2027
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in February 2023.
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Central contact
Sihua Qin
Zhujiang Hospital
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