Plain-English translation of NCT05446805 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Researchers want to understand how depression and early brain changes related to Alzheimer's disease might affect your ability to drive safely. You'll undergo two brain imaging scans (PET scans) that look for specific proteins in the brain, give blood samples, and potentially have a spinal fluid test. The goal is to identify which older adults are at risk for driving problems before accidents happen.
Crashes involving older drivers are a major public health concern, and doctors don't yet have good ways to predict who will experience a decline in driving ability. This study aims to find early warning signs so doctors can help people stay safe on the road or transition away from driving before a problem occurs.
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You will visit the research center to undergo two PET brain imaging scans (which detect specific proteins in your brain) and give a blood sample. You will also either have a lumbar puncture (spinal fluid test) or additional imaging. The researchers will assess your driving ability through standardized testing. The study will help identify connections between depression, early brain changes, and driving performance in older adults.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Enrollment target
~150 participants
Started
June 2021
Primary completion
June 2027
Age range
65 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Kaylin Taylor, MA
Washington University School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.