Plain-English translation of NCT05450328 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether two inhaled medications—Milrinone and Epoprostenol—given before heart bypass surgery can help the heart recover more smoothly when doctors try to stop using the bypass machine. Right now, some patients have trouble coming off the bypass machine after surgery, which can lead to longer recovery times and complications. This study wants to see if giving these medications beforehand prevents that problem.
During heart bypass surgery, the heart and lungs need extra support. When doctors try to stop using the bypass machine, the right side of the heart sometimes doesn't work well enough on its own. This medication combination is designed to strengthen the heart's performance and reduce injury during this critical moment, potentially leading to better outcomes and faster recovery.
You likely qualify if…
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If you enroll, you will be randomly assigned to receive either the two inhaled medications or a placebo (salt water) just before your heart bypass surgery begins. The medications or placebo are given through inhalation as a mist. The study team will monitor your heart function and recovery carefully during and after surgery, tracking whether you have any difficulty coming off the bypass machine and how well you recover overall.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
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