Plain-English translation of NCT05453513 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how depression and cannabis use affect the brain in young people living with HIV. This study will use brain imaging scans and behavioral tests to see how these two conditions may work together and influence brain function. The goal is to learn why some people with HIV who use cannabis and have depression do worse over time.
Depression and cannabis use are both common in people living with HIV, but we don't fully understand how they affect the brain together. This research aims to fill that gap so doctors can better help young adults manage both conditions.
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Over 12 months, you will visit the research center for brain imaging scans (MRI) and complete behavioral tests and questionnaires about your mood and cannabis use. You will need to stop most psychiatric medications for at least one month before starting (your doctor will discuss this with you). The researchers will also check in with you at one year to see how you are doing.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States
Sponsor
University of Miami
Collaborators
National Institute on Drug Abuse (NIDA)
Enrollment target
~280 participants
Started
April 2022
Primary completion
July 2027
Age range
18 Years – 59 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Vilma Gabbay, MD
University of Miami
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.