Plain-English translation of NCT05456035 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether adding social skills training to cognitive behavioral therapy (a common talk therapy for depression) helps teenagers with depression improve faster and more completely. Researchers want to know if teaching teens to better understand other people's thoughts and feelings — skills called 'theory of mind' — can make standard depression therapy work even better.
While talk therapy helps many teens with depression, it doesn't work well enough for everyone. This research explores whether explicitly teaching social understanding skills during therapy could boost the benefits, giving more teens real relief from depression.
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You would be randomly assigned to receive either standard talk therapy for depression, or the same therapy plus special lessons on understanding other people's thoughts and feelings. You'll attend individual therapy sessions with a trained therapist, and complete assessments at the start, after treatment ends, and again 6 months later to measure any changes in your mood and social skills.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
United States
Sponsor
Vanderbilt University
Collaborators
National Institute of Mental Health (NIMH)
Enrollment target
~82 participants
Started
October 2022
Primary completion
August 2027
Age range
13 Years – 17 Years
Last updated on clinicaltrials.gov in October 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Judy Garber, PhD
Vanderbilt University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.