Plain-English translation of NCT05456412 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are studying how a JAK inhibitor affects your immune system when you have active ulcerative colitis. This trial will collect extra blood samples and small tissue biopsies (in addition to your regular medical care) to understand how this medication changes the way your body's immune cells work. By learning more about these changes, doctors hope to predict which patients will benefit most from this treatment.
Current medications for ulcerative colitis don't work the same way for everyone—some people don't respond at all, while others stop responding over time. Researchers believe that understanding how this medication changes your immune system could help doctors choose the right treatment for each patient earlier and more effectively.
You likely qualify if…
You likely don't qualify if…
You will continue your regular medical care and take the JAK inhibitor medication as prescribed by your doctor. In addition, you will have extra appointments where researchers will take small blood samples and tissue biopsies from your colon—procedures that are already common in ulcerative colitis care. These samples help researchers see how the medication is affecting your immune system over time.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
Netherlands
Leiden University Medical Center
Collaborators
Lakefront Biotherapeutics NV
Enrollment target
~60 participants
Started
December 2022
Primary completion
September 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
16 Years – 65 Years
Last updated on clinicaltrials.gov in December 2022.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Philip W Voorneveld, MD, PhD
Leiden University Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.