Plain-English translation of NCT05457140 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study invites young people (ages 12–18) who are hospitalized with their first psychotic symptoms to participate in advanced genetic and immune system testing. Researchers will analyze blood samples using cutting-edge technology to look for genetic changes and immune system problems that might be causing psychosis. Understanding these underlying causes could help doctors diagnose and treat psychosis better in the future.
Most cases of psychosis in young people have no known cause, which makes it hard to treat. Recent discoveries show that in some patients, the immune system mistakenly attacks the brain, or specific genetic changes increase risk—but doctors don't yet know how common these causes are. This study aims to identify which young people have these treatable causes so their care can be personalized.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will have blood drawn once to provide a sample for genetic and immune system analysis. Your parents or guardians may also be asked to provide a blood sample for comparison. The researchers will use advanced technology to sequence your genes and look for immune markers in your blood. Results from this study may help inform your diagnosis and treatment plan, and findings could help improve care for other young people with psychosis in the future.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States