Plain-English translation of NCT05457595 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing carbon ion radiotherapy (CIRT), a specialized type of radiation that uses carbon particles instead of traditional X-rays to treat gynecological cancers that have come back in the pelvis. The study wants to see how well this treatment works, whether it's safe, and whether it helps patients live longer. This treatment is designed for patients who have already received radiation to the pelvis and cannot have surgery to remove the cancer.
Many patients with recurrent gynecological cancer in the pelvis cannot have surgery and have already been treated with standard radiation. This trial exists because carbon ion therapy may be able to deliver stronger doses to tumors while sparing nearby healthy tissue, offering hope for patients with limited treatment options.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will receive carbon ion radiation therapy as your treatment for the recurrent cancer. The medical team will use imaging scans to carefully map out exactly where to direct the radiation, and they may perform a minor surgical procedure beforehand to safely move nearby intestines away from the treatment area if needed. You will be monitored for how well the cancer responds to treatment, how long you survive, and any side effects you experience.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
Italy
Sponsor
CNAO National Center of Oncological Hadrontherapy
Enrollment target
~55 participants
Started
February 2021
Primary completion
February 2028
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amelia Barcellini, MD
CNAO National Center of Oncological Hadrontherapy
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.