Plain-English translation of NCT05462574 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Vanderbilt University are studying pulmonary arterial hypertension (PAH), a serious condition where blood pressure in the lungs becomes dangerously high. They want to understand why fat builds up inside the right chamber of the heart in people with this condition, and whether this fat buildup makes the heart weaker or affects how far you can walk and exercise. By studying your heart with special imaging, measuring how much fat is present, and checking your exercise ability, they hope to discover what causes this problem and eventually find new ways to treat it.
Many people with pulmonary arterial hypertension have difficulty with exercise and their heart function gets worse over time, but doctors don't fully understand why. This study exists to uncover the root causes — specifically, why the heart stores too much fat and how this contributes to the condition — so researchers can develop better treatments.
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You would visit the research center for heart imaging scans (MRI), complete a 6-minute walk test to measure your exercise capacity, and undergo cardiopulmonary exercise testing. Some participants will have repeat scans at four different timepoints over three years to track how the fat in your heart changes over time. Throughout the study, researchers will monitor how you're doing and watch for any health changes.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States
Sponsor
Vanderbilt University Medical Center
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~75 participants
Started
January 2023
Primary completion
September 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Natasha Billard
Vanderbilt University Medical Center
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