Plain-English translation of NCT05464719 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing as a follow-up treatment for patients with a type of blood cancer called large B-cell lymphoma who have already received CAR T-cell therapy. The goal is to see if giving this medication after CAR T-cell therapy can help strengthen the cancer response and prevent the cancer from coming back. Researchers want to understand how well and safely this treatment works when used this way.
CAR T-cell therapy is a powerful cancer treatment, but some patients don't get a complete remission or their cancer returns later. This trial exists to see whether this medication could help improve outcomes by working alongside or after CAR T-cell therapy to fight remaining cancer cells.
You likely qualify if…
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If you join this trial, you will receive the medication by intravenous infusion (through a vein). You will have regular clinic visits for monitoring, including blood tests and imaging scans to track how well the treatment is working and to watch for any side effects. The study involves about 30 patients total, and your doctors will follow your progress carefully to make sure the treatment is safe and effective for you.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
M.D. Anderson Cancer Center
Enrollment target
~30 participants
Started
September 2022
Primary completion
January 2030
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Paolo Strati, MD
M.D. Anderson Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.