Plain-English translation of NCT05465031 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether sacubitril/valsartan—a medication that helps protect the heart—can prevent heart damage in women undergoing treatment for early-stage breast cancer. Some chemotherapy drugs used to treat breast cancer can weaken the heart muscle over time. Researchers want to see if this medication can protect your heart during and after your cancer treatment.
Certain breast cancer treatments, especially chemotherapy drugs, can damage the heart as a side effect. This medication has shown promise in protecting the heart in other situations, and doctors want to know if it can prevent this kind of treatment-related heart damage before it starts.
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You would first take the study medication at a low dose for two weeks to see how well you tolerate it, then increase to the target dose. After that, you would be randomly assigned to either continue the medication or receive a placebo (inactive pill) while you undergo your cancer treatment. You'll have heart ultrasounds and follow-up visits over 24 months to see whether the medication protects your heart from damage.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Poland
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Mateusz Tajstra, MD, PhD, Assoc Prof
3rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia, Katowice; Silesian Center for Heart Diseases
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.