Plain-English translation of NCT05466396 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our COPD research guide →This is a research study that follows people with early signs of chronic obstructive pulmonary disease (COPD)—a condition where the lungs gradually lose function—to better understand how and why the disease progresses. Researchers will track participants over time using lung function tests and chest imaging to identify which factors, like smoking history, contribute most to lung decline. The goal is to gather information that could help doctors predict and manage the disease earlier.
Currently, doctors don't have enough information about how early-stage lung disease develops and what causes some people's lungs to get worse faster than others. This study aims to fill that gap by following patients and collecting detailed information about their lungs, smoking habits, and other health factors.
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As a participant, you would visit the research center multiple times for lung function tests (spirometry) and chest CT scans to take images of your lungs. You'll also answer questions about your health history, smoking habits, and other factors that might affect your lungs. The study follows participants over time—meaning you'd return for follow-up visits so researchers can see how your lung health changes and what factors influence that change. The specific duration and number of visits will depend on the study timeline, but this is an observational study, meaning researchers are watching and measuring rather than testing a new drug or treatment.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
China
Sponsor
Ting YANG
Collaborators
Chinese Academy of Medical Sciences
Enrollment target
~1,550 participants
Started
August 2022
Primary completion
December 2026
Age range
35 Years – 75 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ke Huang, M.D.
China-Japan Friendship Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.