Plain-English translation of NCT05473637 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is trying to better understand cerebral small vessel disease—a condition where the tiny blood vessels in the brain become damaged or narrow. Researchers will take a blood sample from you and use genetic testing to see if your condition is caused by a specific gene mutation or by other factors. Over at least two years, they'll track your symptoms and brain imaging to learn how this disease progresses and affects people differently.
Doctors don't yet have a clear picture of how genetic versus non-genetic small vessel brain disease develops, what warning signs to look for, or how to predict outcomes for individual patients. This study aims to create a detailed map of the disease so doctors can eventually diagnose and treat it better.
You likely qualify if…
You likely don't qualify if…
You will have a blood sample taken for genetic testing that checks five genes known to cause small vessel disease. You will then be grouped based on whether a gene mutation was found. Over the next two years or longer, the research team will follow your health through clinical visits and brain imaging to track any changes in your symptoms and condition.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
Taiwan
Sponsor
National Taiwan University Hospital
Enrollment target
~500 participants
Started
January 2019
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sung-Chun Tang, MD, PhD
National Taiwan University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.