Plain-English translation of NCT05474235 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Mayo Clinic are building a large genetic library to better understand why people develop ALS and other motor neuron diseases. They're collecting blood samples and health information from people diagnosed with ALS, their blood relatives, and healthy volunteers with no family history of the disease. This repository will help scientists discover genetic factors that contribute to these conditions.
ALS and related motor neuron diseases are devastating conditions, but scientists still don't fully understand why some people develop them—especially when there's no family history. By studying the genes and biology of thousands of patients and their families, researchers hope to uncover new clues that could eventually lead to better treatments and prevention strategies.
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If you enroll, you'll visit Mayo Clinic to have blood drawn—a simple procedure where a small sample is taken from your arm. You'll also answer questions about your medical history and family health. The blood samples are stored and used by researchers to study genetic patterns. There is no ongoing medication to take or long-term commitment required; most participation involves a single visit.
AI-generated summary from trial data · Sep 5, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Enrollment target
~3,000 participants
Started
December 2007
Primary completion
December 2038
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2026.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.