Plain-English translation of NCT05474235 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Mayo Clinic is building a large research database to understand the genetic causes of ALS and related motor neuron diseases. Researchers will collect blood samples from people diagnosed with ALS, family members of people with ALS, and healthy volunteers without the disease. This information will help scientists discover why some people develop these conditions and may lead to better treatments in the future.
ALS is a serious disease that affects nerve cells controlling muscles, and researchers don't fully understand why some people develop it or what genetic factors play a role. By studying the genes and blood samples of thousands of people with and without the disease, scientists hope to identify key genetic differences that could unlock new ways to prevent or treat motor neuron diseases.
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If you join this study, you will visit Mayo Clinic (or a partnering location) to have a blood sample drawn and to answer questions about your personal and family medical history. The blood sample will be stored and used for genetic testing and research. Depending on which group you're in—whether you have ALS, are a family member, or are a healthy volunteer—your involvement may be a one-time visit, though researchers may ask for additional samples or health updates in the future as part of their ongoing research.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Enrollment target
~3,000 participants
Started
December 2007
Primary completion
December 2038
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2025.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.