Plain-English translation of NCT05474573 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether combining two imaging tools during brain tumor surgery leads to better outcomes. Surgeons will use a medication called 5-aminolevulinic acid (5-ALA), which makes tumors glow under special light, along with ultrasound imaging. The study compares using both tools together versus using the fluorescence method alone to see if the combination helps remove more of the tumor.
The fluorescence technique with this medication works well, but it has a limitation: surgeons can't see tumor that's hidden underneath normal brain tissue. Ultrasound can help find these hidden areas, so researchers want to know if combining the two methods helps remove tumors more completely and improves outcomes for patients.
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If you join this trial, you will be randomly assigned to have surgery using either both imaging techniques together or the fluorescence method alone. Before surgery, you'll take the fluorescence medication (5-ALA). During your operation, surgeons will use the assigned imaging tools to guide tumor removal. After surgery, you'll have an MRI scan to measure how much tumor was removed, which will be reviewed by radiologists who don't know which imaging method was used.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
Russia
Sponsor
Sklifosovsky Institute of Emergency Care
Enrollment target
~52 participants
Started
September 2022
Primary completion
August 2027
Age range
18 Years – 79 Years
Last updated on clinicaltrials.gov in May 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Alexander Dmitriev, MD
Sklifosovsky Institute of Emergency Care
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.