Plain-English translation of NCT05477134 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Type 2 Diabetes research guide โThis study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
Researchers studied how young people with type 2 diabetes process a natural substance in the body called arginine, which plays a role in insulin production. The trial tested whether giving arginine intravenously could improve how the pancreas works in teenagers and young adults with type 2 diabetes. The study compared young people with type 2 diabetes to healthy young people without diabetes.
Type 2 diabetes in young people is increasing rapidly and tends to be more aggressive than in adults, with the pancreas losing its ability to make insulin quickly. Scientists discovered that young people with type 2 diabetes have lower levels of arginine in their blood, so this trial investigated whether arginine might help improve pancreas function and insulin production.
Participants attended three separate study days over a short period. On the first day, they received stable isotope tracers (harmless radioactive markers used to track body processes) through an IV and had blood drawn repeatedly over 5 hours. On the second day, they drank a glucose solution and completed an oral glucose tolerance test to measure how their body handles sugar. On the third day, they drank another glucose solution and received an intravenous dose of arginine, with blood samples collected to see how this affected their insulin response.
AI-generated summary from trial data ยท Aug 16, 2026 ยท Not medical advice
United States