Plain-English translation of NCT05477212 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a special low-calorie ketogenic diet can help improve two important health problems: how well your gut barrier works (called intestinal permeability) and fatty liver disease. Researchers want to see if this diet, followed for 6 weeks, can reduce fat buildup in your liver and strengthen your gut's ability to protect you from harmful substances.
People with obesity often have both a 'leaky' gut and fatty liver disease, which can cause serious health problems. Doctors don't yet know whether dietary changes like the ketogenic diet can fix these issues, so this study aims to find out.
You likely qualify if…
You likely don't qualify if…
You will follow a very low-calorie ketogenic diet for 6 weeks while the research team closely monitors you. During the study, you'll have blood tests, imaging scans (like ultrasound or special imaging to measure liver fat), and possibly stool samples to check your gut bacteria and how your gut barrier is functioning. The team will track how your liver and gut health change over this 6-week period.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
Italy
Sponsor
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Collaborators
Francesco Russo, Giuseppe, Riezzo
Enrollment target
~30 participants
Started
April 2022
Primary completion
May 2024
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in October 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Giovanni De Perogla, Prof
IRCCS "Saverio de Bellis"
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.