Plain-English translation of NCT05477212 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a special low-calorie ketogenic diet can help improve two important health problems: how well your gut barrier works (called intestinal permeability) and fatty liver disease. Researchers want to see if this diet, followed for 6 weeks, can reduce fat buildup in your liver and strengthen your gut's ability to protect you from harmful substances.
People with obesity often have both a 'leaky' gut and fatty liver disease, which can cause serious health problems. Doctors don't yet know whether dietary changes like the ketogenic diet can fix these issues, so this study aims to find out.
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You will follow a very low-calorie ketogenic diet for 6 weeks while the research team closely monitors you. During the study, you'll have blood tests, imaging scans (like ultrasound or special imaging to measure liver fat), and possibly stool samples to check your gut bacteria and how your gut barrier is functioning. The team will track how your liver and gut health change over this 6-week period.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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