Plain-English translation of NCT05477589 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether a newer chemotherapy combination called CloFluBu works better than the standard combination called BuCyMel when preparing children with acute myeloid leukemia for a stem cell transplant. Both treatments are designed to prepare the body for the transplant by killing leukemia cells and making room for healthy donor cells. The trial will compare how well each medication works and how many side effects patients experience.
Stem cell transplants are an important treatment for children with acute myeloid leukemia, but the chemotherapy used to prepare for the transplant can be very harsh. Researchers want to know if the newer drug combination might be safer or more effective than the standard approach currently used.
You likely qualify if…
You likely don't qualify if…
If you qualify for the main part of the trial, you will be randomly assigned to receive one of the two chemotherapy combinations as conditioning before your stem cell transplant. The chemotherapy will be given over several days in the hospital, followed by the transplant itself. You will need to stay in the hospital during and after the transplant and be monitored closely with blood tests and visits during your recovery, which typically takes several months. Even if you don't qualify for the main trial, you may be asked to join an observational part where your medical information is tracked to help researchers understand transplant outcomes.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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