Plain-English translation of NCT05479409 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Neoplasms research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether radiation therapy—alone or combined with a supplement called beta-alanine, or using a special type of radiation called spatially fractionated radiotherapy—can shrink advanced breast cancers that didn't respond well enough to chemotherapy. The goal is to make these tumors small enough that surgery becomes possible, and to better understand which patients will benefit most from these treatments.
Some women with advanced breast cancer don't shrink their tumors enough with chemotherapy alone, which can leave them unable to have surgery. This trial explores whether adding radiation therapy before surgery can help more patients become candidates for an operation and improve their outcomes.
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You would receive one of three radiation-based treatment approaches over several weeks. The trial will also collect small tissue and blood samples before treatment to understand which patients respond best, and you'll have imaging scans (including ultrasound) before and after treatment to track how your tumor responds. The study team will monitor you closely for side effects and long-term outcomes.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
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