Plain-English translation of NCT05481619 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing how , a medication used to treat ulcerative colitis, affects the bacteria living in your gut. Researchers will collect stool and blood samples from you over one year to see how these bacteria change as you receive treatment, and whether those changes can help predict whether the medication will work well for you.
Ulcerative colitis is a serious bowel disease, but we don't yet have good ways to predict which patients will respond well to treatment. By understanding how this medication changes your gut bacteria, doctors hope to eventually personalize treatment and help patients know in advance whether this therapy is right for them.
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You will receive the medication through an IV infusion at weeks 0, 2, and 6, then every 8 weeks for one year. During this time, you will provide stool and blood samples at baseline and again at 14, 30, and 52 weeks to allow researchers to analyze changes in your gut bacteria and blood markers. The study compares your results to healthy volunteers without bowel disease to see what changes the treatment causes.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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