Plain-English translation of NCT05482399 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether it's safe for older adults with multiple health conditions to stop taking statins (cholesterol-lowering medications) for heart disease prevention. Researchers will measure calcium buildup in your heart arteries and randomly assign you to either keep taking your statin or stop taking it, then follow your health for about two years to see if stopping the medication increases the risk of heart problems or early death.
Doctors are uncertain whether this medication truly helps prevent heart disease in older adults who have multiple other health conditions, and some guidelines now suggest it may be reasonable to stop taking it. This trial will provide clear evidence about which older patients actually benefit from continuing the medication based on how much buildup they have in their heart arteries.
You likely qualify if…
You likely don't qualify if…
If you join, you'll have a heart artery calcium scan (a painless CT imaging test) at the start. Then you'll be randomly assigned to either continue taking your statin exactly as prescribed or stop taking it. You'll receive phone calls to check on your health at 3 months, and then yearly for about 2 years total. Researchers will track whether you experience any heart events or other health changes during the follow-up period.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
Switzerland