Plain-English translation of NCT05485077 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Researchers are studying whether a blood test that looks for specific genetic changes (called polygene methylation detection) can help find colorectal cancer earlier, before symptoms appear. The study will follow about 18,000 adults from a community over 5 years, comparing those with positive blood test results to those with negative results to see if this new blood test is accurate and helpful.
Currently, colorectal cancer screening often relies on uncomfortable procedures like colonoscopies. This trial exists to see if a simple blood test could be an easier way to identify people at higher risk, potentially catching cancer earlier when it's easier to treat.
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You'll start by completing a health questionnaire and providing a blood sample and stool sample at a baseline visit. Within 3 months, you'll have a colonoscopy (a camera test of your colon). Then you'll return for in-person visits at years 1, 3, and 5 for repeat blood tests and colonoscopies, with brief phone check-ins at years 2 and 4. The entire study lasts 5 years, and researchers will track whether you develop colorectal cancer or precancerous polyps during that time.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
China
Sponsor
Singlera Genomics Inc.
Collaborators
Peking University Shougang Hospital
Enrollment target
~18,000 participants
Started
July 2022
Primary completion
July 2028
Age range
40 Years and older
Last updated on clinicaltrials.gov in April 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jin Gu, Doctor
Singlera Genomics Inc.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.