Plain-English translation of NCT05485376 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The PACCS trial is testing whether a pulmonary artery catheter — a thin monitoring tube placed in the heart's main blood vessel — can help doctors manage severe heart failure better when inserted early in treatment. Half of the 400 participating patients will receive this monitoring device within 6 hours of enrollment, while the other half will either not receive it or have it placed much later. The study wants to see if early monitoring and treatment adjustments based on the catheter readings save more lives.
Doctors are unsure whether inserting this monitoring catheter early — and using the information it provides to guide treatment — actually helps patients with severe acute heart failure survive better than standard care alone. This trial will provide clear evidence to guide treatment decisions.
You likely qualify if…
You likely don't qualify if…
If you are randomly assigned to the early catheter group, doctors will place a thin monitoring tube into your heart's blood vessel within 6 hours of enrollment and use the measurements it provides to guide your treatment during your hospital stay. If you are in the comparison group, you will receive standard heart failure care without early catheter monitoring (though one may be placed later if your condition becomes critical). Both groups will be monitored during hospitalization to track survival and other health outcomes.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States
Sponsor
Tufts Medical Center
Enrollment target
~400 participants
Started
August 2022
Primary completion
September 2026
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Karol Walec
nkapur@tuftsmedicalcenter.org
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.